57/M MDR TUBERCULOSIS

 A 57 yr old male lorry driver resident of gopalayapalli came to opd with chief complaints of 

generalised body swelling since 1 month 

decreased urine output since one month

chest pain since 4 days.

HISTORY OF PRESENT ILLNESS:

Patient was apparently asymptomatic one month back later he developed swelling of face followed by abdomen and limbs which is pitting type since one month.

 He had decreased urine output since one month.Intially there was dribbling of urine later there was complete stoppage of urine.

He had chest pain since 4 days which was sudden in onset, dragging type,radiating towards back,and aggravated at night.

H/o low grade fever associated with chills intermittent since one month.

H/o shortness of breath (grade 3) since 1 month 

H/O cough associated with sputum since one month and not relieved on medication.

It is not associated with chest pain and no diurnal variation.

Sputum is blood tinged.

He had 9 sessions of dialysis (on alternate days) from one month last session of dialysis (23/11/22)

PAST HISTORY:

He is diabetic since 15 yrs.He is using gluconorm and since one month he is on insulin.(because of his flucutating blood glucose levels)

He is Hypertensive  since 5 yrs and he is on regular medication.

H/o left hemiparesis s/p thrombolysis 

H/o usage of herbal medication for constipation 

No H/o epilepsy,CAD,Asthma.

No H/o surgeries in  past.

No allergic history.

Renal biopsy was done 1 month ago showed diffuse proliferative pattern of cresents - infection related glomerulonephritis : acute tubular necrosis.

FAMILY HISTORY:

His mother and father are hypertensive.

PERSONAL HISTORY:

Diet:Mixed 

Appetite:decreased 

Sleep: Adequate

Bowel and bladder movements: Decreased urine output since 1 month and had constipation since 6 months

Addictions: Alcoholic since 15 yrs stopped one month back 

Smoker since 30 yrs and stopped 20 yrs back.

GENERAL EXAMINATION:

Patient is conscious, coherent and cooperative.

Moderately built and nourished.

No signs of icterus,cyanosis, clubbing, lymphadenopathy.

He had generalised edema( pitting type),pallor.


Vitals:

PULSE:92bpm,regular,normal volume,no radio radial delay,no radio femoral delay.
BLOOD PRESSURE:130/80mm Hg,in sitting position, in the right arm.
RESPIRATORY RATE:22cpm
TEMPERATURE: afebrile
GRBS:218mg/dl

SYSTEMIC EXAMINATION:

Respiratory system:

Bilateral air entry-present ,

Normal vesicular breath sounds-heard.

Cardiovascular system:

S1 and S2 heard no murmurs heard 

Central nervous system: 

No focal neurological deficit.

Patient is concious coherent.

Higher mental status-

Cranial nerves- intact

Motor system:

  Tone- normal 

 Power- normal

Cerebellar functions-normal 

Abdominal examination: 

soft and non tender, 

No Hepatomegaly, spleen is not palpable.



INVESTIGATION:





















Patient got renal biopsy done in external centre 








Urea-187mg/dl
Creatinine -9.4mg/dl
Phosphorus-5.5 mg/dl
Sputum afb ; negative
CBNAAT:
Rifampicin resistant TB

Pulmonology referral was taken 







PROVISIONAL DIAGNOSIS:
CKD ON MHD
PULMONARY TUBERCULOSIS 

TREATMENT:
T.Nicardia20 mg po bd
T.Nodosis 500mg po bd
T.lasix 80mg po bd
T.Orofer po od
T.shellcal po od
T.met xl 25 mg po od
Inj.HAI s/c according to grbs
Inj.Erythropoietin 400 U s/c weekly once
Collincoff  5ml po tid
Monitor vitals 4th hrly
Grbs monitoring 6th hrly
Syp.Sucral 10ml tid
Inj.Tranexa 500 mg iv/bd
Inj. pantop 40mg iv/bd

PATIENT WAS STARTED ON ATT ON 24 -11-2022 WITH RENAL MODIFICATION DOSE
TAB.BEDAQUITINE 0-2 WEEKS  400 MG DAILY 
                          3-24 WEEKS 200MG THRICE WEEKLY
TAB.LEVOFLOX 1000MG THRICE DAILY 
TAB.CLAFAZIMINE 200MG DAILY 
TAB.HIGH DOSE ISONIAZID 900MG DAILY
TAB.PYRAZINAMIDE 25-35MG/KG THRICE WEEKLY
TAB.ETHAMBUTOL 15-25 MG THRICE WEEKLY
TAB.ETHIONAMIDE 1000MG DAILY
TAB.PYRIDOXINE 100MG DAILY

PATIENT HAS BEEN TAKEN TO OUTSIDE HOSPITAL ON 21-12-22 AS HE IS UNRESPONSIVE AND HAS BEEN DECLARED DEAD DUE TO SUDDEN CARDIAC ARREST.

OUTCOME : MORTALITY


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